Arsenal, similarly, make 10 changes to their side that defeated Rapid Vienna with just Lacazette remaining from that victorious side.
Spurs make eight changes to their heavily rotated midweek side that faced LASK; most notably, Kane returns to the starting line-up after a minor injury.
Arsenal SUBS: Ainsley Maitland-Niles, Mohamed Elneny, Runar Alex Runarsson, Shkodran Mustafi, Eddie Nketiah, Dani Ceballos, Joe Willock.
ARSENAL (3-4-3): Bernd Leno; Rob Holding, Gabriel Magalhaes, Kieran Tierney; Hector Bellerin, Thomas Partey, Granit Xhaka, Bukayo Saka; Willian, Alexandre Lacazette, Pierre-Emerick Aubameyang.
Tottenham SUBS: Joe Hart, Carlos Vinicius, Lucas Moura, Ben Davies, Gareth Bale, Joe Rodon, Harry Winks.
TOTTENHAM (4-2-3-1): Hugo Lloris; Serge Aurier, Toby Alderweireld, Eric Dier, Sergio Reguilon; Moussa Sissoko, Pierre-Emile Hojbjerg; Son Heung-min, Giovani Lo Celso, Steven Bergwijn; Harry Kane.