Opposite number Ole Gunnar Solskjaer has rung the changes for this one. At the back, De Gea is between the sticks and Shaw returns at left-back after a month on the sidelines.
RB LEIPZIG (4-3-2-1): Peter Gulacsi; Nordi Mukiele, Ibrahima Konate, Willi Orban, Angelino; Marcel Sabitzer (c), Amadou Haidara, Kevin Kampl; Christopher Nkunku, Emil Forsberg; Dani Olmo.
MANCHESTER UNITED SUBS: Dean Henderson, Axel Tuanzebe, Lee Grant, Eric Bailly, Paul Pogba, Donny van de Beek, Timothy Fosu-Mensah, Juan Mata, Jesse Lingard, Daniel James, Brandon Williams, Odion Ighalo.
MANCHESTER UNITED (4-2-3-1): David de Gea; Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire (c), Luke Shaw; Scott McTominay, Nemanja Matic; Mason Greenwood, Bruno Fernandes, Alex Telles; Marcus Rashford.